Comorbidity between Alzheimer’s Disease and Seizure Episodes

.................................................................................................... 3 Introduction .................................................................................................4 Tau Hypothesis......................................................................................4 Aβ Hypothesis.......................................................................................4 Neurotransmission..................................................................................5 Synaptophysin.....................................................................................6 Syp KO and Normal Neurotransmission........................................................6 SYP-VAMP2 Complex and Endocytosis......................................................6 ApoE4 and Seizures................................................................................7 AD and Seizures....................................................................................8 Experimental Design......................................................................................9 Methods.......................................................................................................9 Behavioral .................................................................................................9 Molecular ................................................................................................10 Results........................................................................................................12 Behavioral.................................................................................................12 Molecular................................................................................................14 Discussion....................................................................................................15 AD and Syp KO......................................................................................16 Neurotropic vs. Neurotoxic Effects of Aβ........................................................16 ApoE4................................................................................................18 Cognitive impairments in AD......................................................................18 Conclusion...................................................................................................19 Acknowledgements.........................................................................................19 References.....................................................................................................20